Table 2 Putative tapeworm drug targets for which there is a TBLASTX hit in predicted S. erinaceieuropaei gene transcript (E-value >1e-10)
Putative E. multilocularis drug targets a | TBLASTX E-value | Percentage completeness b | Percentage identity of match | S. erinaceieuropaei gene ID |
|---|---|---|---|---|
Thioredoxin glutathione reductase (TGR) | 8e-77 | 28 | 73 | SPER_0002850001 |
Fatty acid amide hydrolase | 3e-59 | 39 | 50 | SPER_0002366401 |
Adenine nucleotide translocator | e-161 | 79 | 84 | SPER_0000599901 |
Inosine 5′ monophosphate dehyrogenase | 2e-81 | 42 | 79 | SPER_0001958401 |
Succinate semialdehyde dehyrogenase | 1e-54 | 25 | 68 | SPER_0002970001 |
Ribonucleoside diphosphate reductase | e-149 | 67 | 83 | SPER_0000698501 |
Casein kinase II | e-114 | 47 | 93 | SPER_0000626801 |
Hypoxanthine guanine phosphoribosyltransferase | 2e-35 | 57 | 43 | SPER_0000257601 |
Glycogen synthase kinase 3 | 2e-69 | 50 | 84 | SPER_0001364001 |
Proteasome subunit | 4e-21 | 36 | 59 | SPER_0002270001 |
Calmodulin | 1e-94 | 100 | 98 | SPER_0000219201 |
FK506 binding protein | 3e-43 | 100 | 70 | SPER_0000627901 |
UMP-CMP kinase | 6e-24 | 40 | 73 | SPER_0000808401 |
Na+/K+ ATPase | 0 | 40 | 91 | SPER_0000981501 |
Carbonic anhydrase II | 3e-39 | 84 | 60 | SPER_0002854501 |
NADH dehydrogenase subunit 1 | 3e-22 | 55 | 62 | SPER_0000882501 |
Translocator protein | 1e-26 | 95 | 44 | SPER_0002949701 |
Elongation factor 2 | 0 | 81 | 70 | SPER_0001150701 |
Cathepsin B (cysteine protease) | 6e-93 | 62 | 61 | SPER_0002586301 |
Dual-specificity mitogen activated protein | 3e-54 | 27 | 86 | SPER_0000571801 |
Purine nucleoside phosphorylase | 3e-77 | 69 | 61 | SPER_0000360401 |