Effect size of the top replicated loci. Box plots represent the effect sizes for the top k loci from the discovery cohort that are replicated in the validation cohort. The effect size is measured as the difference on the beta value scale between the two treatment group means. (a) Box plots for the top k=100000 loci replicated in the Ontario-EBV data set. (b) Box plots for the top k=100000 loci replicated in the TCGA-KIRC data set. EBV, Epstein–Barr virus; Funnorm, functional normalization; w, with.