Comparison to batch effect removal tools SVA, RUV and ComBat. (a) Like Figure 2a, an ROC curve for the Ontario-EBV data set. (b) Like Figure 3a, an ROC curve for the TCGA-KIRC data set. (c) Like Figure 3b, a concordance curve between the validation cohort from 450k data and the 27k data for the TCGA-KIRC data set. (d) Like Figure 4a, concordance plots between results from the 450k array and the 27k array for the TCGA-AML data set. (e) Like Figure 5a, an ROC curve for the Ontario-Blood data set. AML, acute myeloid leukemia; EBV, Epstein–Barr virus; Funnorm, functional normalization; ROC, receiver operating characteristic.