Figure 5
From: Functional normalization of 450k methylation array data improves replication in large cancer studies
Performance improvements on blood samples data set. (a) ROC curve for replication of case–control differences between blood samples from colon cancer patients and blood samples from normal individuals, the Ontario-Blood data set. The validation data set was constructed to show an in silico batch effect. (b) ROC curve for identification of probes on the sex chromosomes for the Ontario-Sex data set. Sex is confounded by an in silico batch effect. Both evaluations show the good performance of functional normalization. Funnorm, functional normalization; ROC, receiver operating characteristic.