Improvements in replication of tumor subtype heterogeneity. In the AML data set from TCGA, the same samples have been assayed on 450k and 27k arrays. (a) Concordance plots between results from the 450k array and the 27k array. (b) ROC curves for the 450k data, using the results from the 27k data as gold standard. AML, acute myeloid leukemia; Funnorm, functional normalization; ROC, receiver operating characteristic; TCGA, The Cancer Genome Atlas.