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Table 1 Regulons culled from the literature compared to TFOE defined regulons

From: Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network

TF Name Type of analysis a Reference regulon b TFOE regulon c Overlap d P value Reference
Rv0022c whiB5 OE 61 436 59 <0.001 [4]
Rv0182c sigG OE 7 20 4 <0.001 [5]
Rv0195   KO 179 27 1 0.708 [6]
Rv0465c ramB KO 2 15 1 0.007 [8]
Rv0586 mce2R KO 4 11 4 <0.001 [9]
Rv1909c furA KO 1 12 1 0.003 [11]
Rv2034   Various 11 67 0 1.000 [12]
Rv2359 furB KO 23 6 5 <0.001 [13]
Rv3124 moaR OE 4 9 4 <0.001 [14]
Rv3133c dosR KO 48 127 45 <0.001 [15]
Rv3557c kstR2 KO 15 19 15 <0.001 [16]
Rv3574 kstR KO 70 74 32 <0.001 [16]
  1. For each transcription factor set of genes differentially expressed by overexpression was compared to a previously reported regulon.
  2. aThe type of analysis done in the reference (OE, KO, or various).
  3. bThe number of genes in the previously published regulon.
  4. cThe number of genes differentially expressed in our assay.
  5. dThe number of genes that change in both our assay in prior reports.
  6. KO, knockout; OE, overexpression.