Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network

Table 1 Regulons culled from the literature compared to TFOE defined regulons

TF	Name	Type of analysis ^a	Reference regulon ^b	TFOE regulon ^c	Overlap ^d	P value	Reference
Rv0022c	whiB5	OE	61	436	59	<0.001	[4]
Rv0182c	sigG	OE	7	20	4	<0.001	[5]
Rv0195		KO	179	27	1	0.708	[6]
Rv0465c	ramB	KO	2	15	1	0.007	[8]
Rv0586	mce2R	KO	4	11	4	<0.001	[9]
Rv1909c	furA	KO	1	12	1	0.003	[11]
Rv2034		Various	11	67	0	1.000	[12]
Rv2359	furB	KO	23	6	5	<0.001	[13]
Rv3124	moaR	OE	4	9	4	<0.001	[14]
Rv3133c	dosR	KO	48	127	45	<0.001	[15]
Rv3557c	kstR2	KO	15	19	15	<0.001	[16]
Rv3574	kstR	KO	70	74	32	<0.001	[16]

For each transcription factor set of genes differentially expressed by overexpression was compared to a previously reported regulon.
^aThe type of analysis done in the reference (OE, KO, or various).
^bThe number of genes in the previously published regulon.
^cThe number of genes differentially expressed in our assay.
^dThe number of genes that change in both our assay in prior reports.
KO, knockout; OE, overexpression.

ISSN: 1474-760X