Manually constructed TFOE network. Genes were grouped into sets with similar regulation patterns and the interaction of each TF with each set was mapped. The size of each set of genes is indicated beneath the gene set name. The color of each TF indicates whether the regulatory influence of that is primarily to repress (blue) or induce (orange) genes. Genes repressed by multiple TFs and those with no change in expression were enriched for essential genes, many of which have GO terms assigned to them.