Skip to main content

Table 1 Single nucleotide polymorphisms that correlate with Δphotoperiod

From: Genetic adaptation of the human circadian clock to day-length latitudinal variations and relevance for affective disorders

SNP

Gene

Kendall's correlation P valuea

Ï„ rankb

FSTrankc

LnRsb rankd

Functional annotatione

    

Biaka-Orcadian

Biaka-Maya

CEPH

CHB + JPT

 

Core circadian

       

rs11048980

ARNTL2

7.167 × 10-8

1.000

0.506

0.000

0.79

0.89

intronic

rs6811520

CLOCK

1.444 × 10-5

0.978

0.831

0.466

0.84

0.87

intronic

rs11038695

CRY2

1.626 × 10-4

0.957

0.624

0.247

0.64

0.33

intronic; in LD (r2 = 0.93 in CEPH) with rs11038697 (within ARNTL and CLOCK binding sites)

rs4789846

CSNK1D

5.546 × 10-5

0.970

0.601

0.000

0.69

0.84

intronic

rs5995572

CSNK1E

1.053 × 10-5

0.984

0.973

0.515

0.05

0.14

intronic

rs17654772

NPAS2

2.549 × 10-7

0.998

0.615

0.377

0.84

0.43

intronic

rs4663868

PER2

9.462 × 10-5

0.962

0.286

0.219

0.97

0.90

intronic

Circadian hits (RNAi screen)

      

rs2583836

ABL1

3.071 × 10-7

0.995

0.936

0.311

0.97

0.63

intronic

rs12713670

ANTXR1

4.331 × 10-9

1.000

0.108

0.468

0.57

0.58

intronic

rs12193789

ASCC3

9.351 × 10-6

0.994

0.371

0.166

0.94

0.96

intronic

rs11581556

ATF6

7.326 × 10-7

0.995

0.845

0.615

0.96

0.90

intronic

rs5996513

BCR

8.368 × 10-6

0.996

0.932

0.626

0.11

0.21

intronic

rs8

CDK6

9.581 × 10-7

0.998

0.800

0.299

0.82

0.85

intronic

rs2304593

CMTM7

5.239 × 10-6

0.993

0.370

0.000

0.16

0.34

intronic

rs2279103

CTDP1

6.403 × 10-8

0.999

0.745

0.276

0.70

0.50

missense T340M

rs657801

DENND2D

9.280 × 10-6

0.983

0.797

0.352

0.94

0.94

intronic

rs2354420

EMP2

6.654 × 10-6

0.988

0.657

0.167

0.08

0.18

intronic

rs11792480

ENG

1.281 × 10-5

0.989

0.954

0.041

0.83

0.68

intronic

rs550897

FAM55D

3.670 × 10-8

0.998

0.848

0.308

0.99

0.99

missense Y398H

rs1011814

FGF10

6.501 × 10-7

0.994

0.926

0.513

0.99

1.00

intronic

rs17679400

FHIT

1.3645 × 10-7

0.998

0.742

0.255

0.26

0.20

intronic

rs1416995

GPR158

2.921 × 10-7

0.997

0.995

0.973

0.04

0.29

intronic

rs12787863

GRM5

3.597 × 10-7

0.996

0.860

0.088

0.94

0.81

intronic

rs17422

HCFC1

1.623 × 10-7

0.997

0.936

0.004

0.84

0.81

intronic

rs11586100

HNRNPR

4.271 × 10-6

0.984

0.968

0.248

1.00

1.00

intronic

rs1122821

HOMER3

8.660 × 10-6

0.980

0.479

0.013

0.46

0.61

intronic

rs2158622

JAZF1

5.810 × 10-6

0.991

0.716

0.000

0.04

0.49

intronic

rs9952025

LIPG

1.269 × 10-5

0.994

0.764

0.787

0.18

0.11

intronic

rs955816

MARCH4

1.735 × 10-6

0.991

0.910

0.186

0.85

0.37

intronic; in LD (r2 = 0.80 in CHB + JPT) with rs11691655 (within ARNTL and CLOCK binding sites)

rs566125

MMP3

1.247 × 10-6

0.995

0.716

0.254

0.98

0.96

intronic

rs710080

MPG

1.641 × 10-7

0.998

0.989

0.840

0.44

0.54

5' UTR variant

rs1053000

PFKP

9.234 × 10-6

0.988

0.971

0.152

1.00

1.00

3' UTR variant

rs578096

PTGER3

1.272 × 10-5

0.985

0.733

0.000

0.77

0.51

intronic

rs2020945

PWP2

5.640 × 10-8

0.998

0.965

0.780

0.62

0.50

missense D25N

rs11617401

RAB20

5.288 × 10-7

0.997

0.791

0.000

0.89

0.47

intronic

rs1204897

RCC2

7.331 × 10-6

0.987

0.540

0.496

0.37

0.46

intronic

rs17682132

RCVRN

3.072 × 10-7

0.998

0.943

0.000

0.96

0.33

intronic

rs492786

SCARA3

7.034 × 10-6

0.982

0.197

0.417

0.82

0.68

intronic

rs9812406

SCHIP1

1.487 × 10-7

0.998

0.989

0.577

0.60

0.68

intronic

rs6695715

SEC16B

1.113 × 10-5

0.982

0.247

0.123

0.44

0.78

intronic

rs2224957

SH3GL2

2.399 × 10-7

0.996

0.896

0.180

0.01

0.04

intronic

rs6081636

SLC24A3

5.980 × 10-6

0.988

0.612

0.246

0.16

0.47

intronic

rs830142

SLC8A2

7.264 × 10-6

0.993

0.325

0.000

0.67

0.80

intronic

rs732611

TBC1D9

4.321 × 10-8

0.999

0.943

0.000

0.78

0.87

intronic

rs1514685

TPO

5.156 × 10-8

0.998

0.720

0.199

0.23

0.17

intronic

rs11760463

WDR86

1.279 × 10-5

0.975

0.854

0.378

1.00

0.97

intronic

rs10227271

WNT2

6.406 × 10-6

0.983

0.971

0.173

0.07

0.70

intronic

Mouse circadian/sleep disturbance

     

rs3753472

ADORA1

1.155 × 10-5

0.981

0.941

0.445

0.80

0.21

intronic

rs2830044

APP

5.206 × 10-6

0.985

0.833

0.311

0.53

0.71

intronic

rs228188

BTBD9

3.149 × 10-6

0.993

0.895

0.155

1.00

0.72

intronic

rs7801807

CADPS2

1.465 × 10-5

0.993

0.891

0.000

0.90

0.90

intronic

rs17818083

EBF2

2.924 × 10-6

0.992

0.939

0.000

0.11

0.24

intronic

rs809192

FYN

1.270 × 10-5

0.987

0.804

0.061

0.82

0.63

intronic

rs2134294

HCRTR2

5.923 × 10-6

0.986

0.741

0.405

1.00

0.96

intronic

rs17187747

KCNB2

6.700 × 10-7

0.994

0.652

0.349

0.33

0.54

intronic

rs12762512

KCNMA1

4.857 × 10-8

0.999

0.307

0.494

0.29

0.33

intronic

rs1943620

NCAM1

9.774 × 10-9

0.999

0.838

0.410

0.18

0.19

intronic

rs10774910

NOS1

1.693 × 10-6

0.990

0.916

0.118

1.00

1.00

intronic

rs2294678

NOX3

1.530 × 10-5

0.980

0.950

0.172

0.18

0.87

intronic

rs12043436

OMA1

2.192 × 10-6

0.991

0.840

0.129

0.99

0.95

intronic

rs595146

PHLPP1

8.637 × 10-6

0.999

0.877

0.000

0.34

0.29

intronic

rs10508958

PRKG1

4.490 × 10-7

0.996

0.873

0.193

0.99

0.69

intronic

rs3733553

PRKG2

1.212 × 10-5

0.980

0.868

0.823

0.96

0.99

intronic

rs752579

RAI1

1.023 × 10-5

0.981

0.954

0.473

1.00

0.96

intronic

rs2271733

RAX

1.464 × 10-5

0.984

0.688

0.443

0.89

0.63

missense D44E

rs10519052

RORA

3.667 × 10-6

0.991

0.448

0.234

0.68

0.68

intronic

rs968357

RORB

2.655 × 10-6

0.992

0.755

0.560

0.63

0.83

intronic

rs2236409

TNC

9.344 × 10-6

0.985

0.455

0.063

0.40

0.96

intronic

rs7300641

TPH2

1.676 × 10-5

0.975

0.827

0.400

0.01

0.02

intronic

rs4445877

UBE3A

1.849 × 10-5

0.974

0.939

0.607

0.90

0.99

intronic

Mendelian diseases causing sleep disturbance in humans

     

rs5909187

CDKL5

6.275 × 10-6

0.987

0.550

0.017

0.27

0.55

intronic

rs11603330

DHCR7

2.848 × 10-7

0.995

0.806

0.479

0.75

0.98

intronic

rs13414769

HDAC4

3.134 × 10-5

0.969

0.573

0.264

0.94

0.98

intronic

rs2239464

MECP2

3.189 × 10-7

0.996

0.663

0.517

0.48

0.28

intronic

rs858953

NRXN1

1.226 × 10-9

1.000

0.780

0.254

0.83

0.49

intronic

rs8137951

SHANK3

3.148 × 10-6

0.989

0.517

0.127

0.59

0.44

intronic

rs12406072

SLC2A1

2.430 × 10-5

0.980

0.952

0.518

0.56

0.52

intronic

Melanopsin signaling

      

rs308039

GNA11

2.387 × 10-5

0.972

0.568

0.079

0.06

0.29

intronic

rs4745672

GNAQ

4.391 × 10-6

0.986

0.790

0.610

1.00

0.92

intronic

rs2476197

INADL

1.834 × 10-7

0.998

0.943

0.252

0.92

0.96

intronic

rs2224361

PLCB4

4.222 × 10-5

0.991

0.426

0.000

0.32

0.37

intronic

rs2138004

PRKCA

3.025 × 10-5

0.971

0.974

0.708

0.24

0.33

intronic

rs10910030

PRKCZ

1.588 × 10-8

0.999

0.771

0.234

0.18

0.27

intronic

rs1392171

TRPC7

2.123 × 10-6

0.993

0.371

0.000

0.48

0.70

intronic

  1. aKendall's correlation P values for the correlation between allele frequency and Δphotoperiod; bpercentile rank in the distribution of Kendall's correlation coefficients (τ) calculated for minor allele frequency (MAF)-matched SNPs; cFST percentile rank in the distribution of SNPs showing a similar average MAF (calculated over all populations); dlnRsb percentile rank; einformation on ARNTL, CLOCK and CRY1 binding sites was obtained from [80]; significant values are shown in bold. CEPH, 1000 Genomes Phase I data for Utah Residents with Northern and Western European ancestry; CHB + JPT, 1000 Genomes Phase I data for Han Chinese in Beijing plus Japanese in Tokyo; RNAi, RNA interference; SNP, single nucleotide polymorphism, UTR, untranslated region.