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Figure 5 | Genome Biology

Figure 5

From: Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach

Figure 5

Local and distant eQTL associations for eSNP rs11074938 involving CIITA . (A) Manhattan plot showing association on chromosome 16p13. (B) Regional association plot for CIITA demonstrating peak association for rs11074938 located in intron 13 of CIITA. (C) Box-plot showing allelic association of rs11074938 with levels of CIITA expression across 281 individuals. (D) Circular plot illustrating genomic location of eQTLs for rs11074938 in B cells. From outside to inside: chromosome number; relative distance along chromosome; coloured dots are cis and trans-eQTLs (size relative -log10 P value as per legend); the outer grey dot is a cis-eQTL for CIITA while inner blue dots are trans-eQTLs; lines indicate genes regulated in trans rendering these as potential CIITA targets, only eQTL mapping to genes with P <3 × 10-4 in the dataset (n = 281) have been shown. (E) Association of rs11074938 with levels of pan MHC class II protein across 37 individuals quantified using multi-parametric flow cytometry. Difference in measured protein levels between homozygous individuals with the A allele as compared to the G allele was significant (*denotes Kruskall-Wallis P = 0.02; MFI = Median fluorescence intensity; data shown have been normalised to control isotype staining).

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