Evolution of extensively drug-resistant Mycobacterium tuberculosisfrom a susceptible ancestor in a single patient

Table 1 Resistance mutations acquired over time in serial isolates from patient

Gene	Protein/RNA change	Resistance	Reference
gyrB	S447F	FLQ	[13]
gyrB	T500N	FLQ	[14]
mshA	V238 frameshift	ETH	[15]
mshA	A342E	ETH	[15]
rpoB	S450L	RIF	[16]
rrs	A514C	STR	[17]
gid	G37 Stop	STR	[18]
rrs	A1401G	AMK/KAN	[19]
katG	W300R	INH	[20]
katG	P7 frameshift	INH	[21]
embB	N644I	EMB
embB	D1024N	EMB

ISSN: 1474-760X