Figure 1
From: MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis
Illustration of the MSEA methods. (A) MSEA-clust. The x-axis displays a schematic of the protein amino acid sequence. The red vertical lines indicate mutations affecting the protein sequence, which in turn contribute to the mutation accumulation score (MAS, blue line, y-axis) and mutation enrichment score (MES). (B) MSEA-domain. The top portion represents the amino acid sequence of a protein with three domains, two of which overlap. The lower panels display the binomial representation of the M1, M2, and M3 models to interpret protein domains, for which 1 indicates amino acids included in a domain(s), and 0 denotes amino acids not represented by a domain(s).