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Figure 2 | Genome Biology

Figure 2

From: Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations

Figure 2

Performance statistics of mutation effect prediction algorithms. Based on the prediction results of (A) the non-neutral (n = 849) and neutral (n = 140) single nucleotide variants (SNVs) included in this study and (B) the non-neutral (n = 188) and neutral (n = 109) SNVs not present in the COSMIC database, the accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and composite score for each predictor are plotted. Error bars represent the 95% CIs generated by bootstrapping. Single/independent predictors are shown in blue bars, and meta-predictors are shown in orange bars.

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Genome Biology

ISSN: 1474-760X

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