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Figure 7 | Genome Biology

Figure 7

From: Sequence specificity incompletely defines the genome-wide occupancy of Myc

Figure 7

Two models of Myc-Max recruitment. The top panel illustrates the prevailing view of E-box recruitment of Myc-Max followed by interactions of Mediator and other factors that affect transcription. The bottom panel is an alternative view supported by the results presented here in which Myc-Max is recruited by the transcription machinery and bound with a relaxed sequence requirement to promoter DNA. We suggest that the Myc-Max occupancy of the promoter region helps keep the promoter free of nucleosomes and the resulting increased accessibility of the promoter is responsible for the amplification of gene expression caused by Myc.

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