Figure 2

Density of heterozygous variation across the MHC. Plots of heterozygous variant density (using 10 kb bins) across the MHC on macaque chromosome 4. As expected, the density of variants is higher, and more widespread, in the M1/M3 heterozygotes compared with both the M1 and M3 homozygotes. As shown in the upper leftmost plot, the occasional peaks of variation detected in the M1 and M3 homozygotes correspond to polymorphic loci upon which reads for multiple alleles mapped.