Figure 7
From: A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data
Comparison of clonality for SNVs and sCNAs of single genes in sAGP-CCF joint distribution heatmaps (A, B) or scatter plots (C, D). (A) sAGP-CCF 2D heatmap for a hypothetical sample, showing characteristic density peaks as explained in the main text. (B) Actual heatmaps for four breast cancer-related genes: TP53, PIK3CA, GATA3, and MAP3K1. Sample counts vary by gene, according to how many were removed due to missing values for either sAGP or CCF. (C, D) Scatter plot of sAGP-CCF for TP53 and PIK3CA, divided by PAM50 gene expression subtypes. We excluded seven Normal-like samples due to low count.