Figure 2
From: A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data
Example of intra-tumor heterogeneity (breast tumor sample TCGA-A1-A0SD). (A) BAF and LRR tracks for binned segments, showing different levels of contraction along the genome. Segments shown in the same color (black, red, green) have similar cellular fractions, and each may represent events in the same clonal population. (B) BAF-LRR plot for the same sample, showing different levels of contraction for segments of different colors. (C) MCMC fitting of sAGP distribution supports three modes, with peaks around sAGP =0.5, 0.4, and 0.2. The distribution of sAGP is indicated by the light blue histogram, while the fitted three-Gaussian density is shown in dark green.