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Table 3 Association of clinical and genetic parameters with overall survival in the discovery cohort

From: Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas

Parameter

n

P-value

HR

Age >50 years

23/98

0.187

1.57 (0.80-3.07)

Pre-operative KPS score <80

5/83

0.101

2.42 (0.79-7.05)

Pre-operative use of steroids

18/85

0.068

1.84 (0.99-3.58)

Pre-operative mass effect

37/71

0.0008

3.31 (1.61-6.73)

Pre-operative enhancement

35/79

0.031

2.16 (1.05-4.43)

Partial resection

69/90

0.029

2.85 (1.19-7.47)

Oligodendroglial histology

42/98

0.016

0.47 (0.25-0.87)

IDH1 or IDH2 mutation

86/97

0.071

0.47 (0.21-1.07)

1p/19q co-deletion without 10q loss

41/98

0.0001

0.30 (0.15-0.58)

Loss of 10q without 1p/19q co-deletion

15/98

0.001

2.91 (1.53-5.55)

  1. Results were determined using a log rank test. n, patients in subgroup compared with total number of patients with available data for each parameter; HR, hazard ratio (95% confidence interval). KPS, Karnofsky Performance Score.
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