Figure 3

Kaplan Meier plots for distal 10q loss and 1p/19q co-deletion in (A) discovery, (B) validation and (C) confirmation cohorts. The dark blue line indicates loss of distal 10q without 1p/19q co-deletion versus the rest of the cohort (n =15, P-value =0.001 in (A), n =8, P-value =0.018 in (B), and n =14, P-value =0.0018 in (C). The green line indicates 1p/19q co-deletion without distal loss of 10q (n =38, P-value =0.0001 in (A), n =41, P-value =0.0005 in (B), and n =47, P-value =0.74 in (C). The light blue line indicates 10q loss and 1p/19q co-deletion (n =3, P-value =0.39 in (A), n =4, P-value =0.94 in (B), and n =0 in (C). The grey line indicates neither 10q deletion nor 1p/19q co-deletion (n =42 in (A), n =73 in (B), and n =123 in (C). The y-axis represents the fraction of patients alive, cumulative survival (Cum. Surv.), and the x-axis time in months. Censored patients are indicated with a vertical bar.