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Figure 2 | Genome Biology

Figure 2

From: Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data

Figure 2

Grid plot of a simulated, subclonal tumor sample. (a) Genome integer CNs in the aneuploid subclone A. (b) Genome integer CNs in the less variable subclone B. (c) Grid plot from sample with 20% normal cell contamination, 30% cells from subclone A and 50% cells from subclone B. In grid plots each data point represents average CNs of a genome segment. Different colors represent genome segments with different behaviors in terms of their average CNs across the sample cells. In this grid plot each third of the genome results in a separate grid pattern (blue for subclone B integer CNs (1,1), black for (0,1) or red for (1,2)) their size determined by the fraction of subclone A cells. The three grids are positioned in a larger grid for which the size is determined by the larger fraction of subclone B cells (green).

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