Figure 11

Sample 16 VAFs fit expected VAFs along chromosome 17. Sample 16 VAFs (points) and expected VAF levels (horizontal lines; Figure 10) along chromosome 17 given subclone A CN estimates and its sample cell fraction α. This sample has 1,232 detected mutations, which is many more than the median 156 of the 52 RESPONSIFY samples. We see an almost perfect fit of the observed VAFs to those expected. For color coding of VAFs, see text. This figure also shows how the mutation rate differs across the chromosome, a different type of heterogeneity studied by Lawrence et al. [29]. The purity of this sample is unknown and is imputed to 90%.