Figure 5
From: Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes
Identification and characterization of de-repressed genes. (A) Average DNA methylation percentage (heat bar) and densities of ChIP-seq tags for H3K4me3 (reds), H3K27ac (greens), and RNAPII (blues) are plotted relative to the transcription start sites of de-repressed genes in HCT116 and DKO1. Light-colored dashed lines represent the marks in DKO1 cells. (B) Venn diagram displaying the overlap of the promoters of de-repressed genes and H3K4me3 peaks unique to DKO1 cells. (C) Gene Ontology results for the 1,086 de-repressed genes in DKO1 (top) and the subset of those genes whose promoters have DKO1-unique H3K4me3 peaks (bottom).