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Table 1 Summary of in vivo tumourigenesis assay

From: Polygenic in vivovalidation of cancer mutations using transposons

Generation Transposase Transposons Animals (n) Animals with tumours (n) Median tumour latency (weeks) Animals with tumours (%)
F0 chimaeras + + 21 8 85.5 38
F0 chimaeras - + 20 3 89.9 15
F1 animals + + 65 44 108.4 67
F1 animals + + (p53.R270H) 20 6 74.9 30