Mutation patterns are concordant between primary and metastatic tumors and consistent with TCGA. (A) Most commonly mutated gene frequencies are similar to those of the TCGA non-hypermutated cohort, with minor differences likely due to increased sequencing depth and more advanced disease. (B, C) Mutations are highly concordant between primary and metastatic tumors. Shared mutations are in dark purple, private to primary is light red, private to metastasis in light blue. Mutations that are loss-of-function (nonsense, frameshift, or splice site) or that occur in at least five samples in Cosmic are marked with an orange dot.