Figure 3
From: Checkpoints couple transcription network oscillator dynamics to cell-cycle progression
Dynamics of transcripts in Cdc20-depleted cells, cyclin-depleted cells, and cycling WT cells. Heat maps depicting mRNA levels of 208 genes that remain periodic in cells arrested with CDK `on’ (P GALL -CDC20;cdc20) (a). Heat maps show behaviors of the same genes in arrested cells with CDK `off’ (Δclb1,2,3,4,5,6) (b), and in normally-cycling WT (c) cells. Each row represents the same gene in all three conditions (Additional file 3). Heat maps depicting mRNA levels of SBF- and MBF-regulated genes from annotated lists generated from two separate studies: Ferrezuelo et al. [24](d) and Eser et al. [23](e) in CDK `on’ (left) and WT (right) cells. Transcript levels are depicted as log2-fold change relative to the mean expression of each gene and are depicted as in Figure 2. Each column represents a time point.