Skip to main content
Figure 7 | Genome Biology

Figure 7

From: Cancer progression modeling using static sample data

Figure 7

Model constructed using the TCGA dataset and its association with clinical and genetic variables. (A) Breast cancer progression tree. There were only eight normal-like samples and no distinct cluster was identified. The bifurcation structure and the order of the molecular subtypes are almost identical to those observed in the METABRIC model. (B-D) The molecular grade, overall mutation rate and CNA frequency were highly correlated with the N-B (first column) and N-H (second column) progression branches. CNA, copy number alteration; N-B, normal through luminal to basal phenotype; N-H, normal through luminal to HER2+ phenotype; TCGA, The Cancer Genome Atlas.

Back to article page