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Figure 1 | Genome Biology

Figure 1

From: Unraveling the clonal hierarchy of somatic genomic aberrations

Figure 1

Local versus global approaches to clonality analysis. The local optimization approach to compute global admixture (1 - purity) and ploidy is schematically explained and compared with a global optimization approach on two cancer samples with different levels of lesion heterogeneity. Copy number neutral regions show nominal AF of 0.5; AFs of mono-allelic deletions depend on lesion clonality and on global admixture. Arrows point to lesions used by global (red) or local (blue) approach. For sample 1 showing a profile compatible with clonal cell population (that is, each lesion demonstrates approximately the same AF value), the two approaches return equivalent estimates. For sample 2 (high heterogeneity) the local approach focuses on lesions with the highest level of clonality (blue arrows), resulting in a realistic estimate of the sample admixture.

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