Genome-wide DNA methylation profiles in progression to in situand invasive carcinoma of the breast with impact on gene transcription and prognosis

Table 1 Differential DNA methylation during progression of breast cancer

	Healthy-DCIS^a	DCIS-IDC
Total differentially methylated CpGs^b	16,949	2,000
Total represented genes	5,659	1,076
Total differentially methylated gene regions^c	1,249	166
Total represented genes	1,011	154

^aAnalysis performed in two independent datasets. Only concordant results in both datasets are reported. ^bAll individual CpGs differentially methylated between normal and DCIS, and between DCIS and IBC. ^cGene regions differentially methylated between normal and DCIS, and between DCIS and IBC. Differential methylation was determined by SAM analysis (FDR q-value <1% and difference in median of groups >10%).

ISSN: 1474-760X