Figure 3From: Methylome analysis identifies a Wilms tumor epigenetic biomarker detectable in bloodLevels of methylation in serum cfDNA during WT treatment. Levels of %Mmean (for 14 CpGs within DMR-2) show significant differences between controls and pre-op samples (p = 0.010), controls and post-op samples (p = 0.017), pre-chemotherapy and pre-op (p = 0.028) and pre-chemotherapy and post-op (p = 0.047; all by 2-tailed T-test). Data shows increasing levels of methylated cfDNA associated with WT necrosis. Level of significance is shown by * (<0.05) or ** (<0.01) with horizontal lines indicating the respective comparison).Back to article page