Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

Table 1 Branch:trunk indices (ITB) from M-seq for germline VHL mutant and sporadic ccRCC tumors

Tumor code	Age of patient (years)	Germline or sporadicVHLmutation/methylation	Tumor stage	ITB
Tumor 3 (left)	33	Germline	I	0.06
EV006	65	Sporadic	IV	0.07
EV003	64	Sporadic	IV	0.17
Tumor 2 (right)	33	Germline	III	0.19
EV007	59	Sporadic	IV	0.56
RMH008	64	Sporadic	III	0.64
EV002	59	Sporadic	IV	0.67
EV005	79	Sporadic	IV	0.75
EV001	75	Sporadic	IV	0.84
RMH002	63	Sporadic	IV	0.93
RMH004	61	Sporadic	IV	1.81
RK26	47	Sporadic	II	2.35

ISSN: 1474-760X