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Table 2 Summary of common deleted regions in relapse samples

From: Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas

Chromosome

Common deleted region coordinates

Sample ID

Genes

Function in B cells

1

117064566-117131520

1R3, 3R, 14R

CD58

Genetically inactivated in DLBCL to escape immune recognition [24]

4

961371-967030

1R1, 2R, 13R

DGKQ

Not known

13

111885580-111996434

1R1, 2R, 3R, 14R

ARHGEF7

Guanine nucleotide exchange factor for RAC1 GTPases that plays an important role in mature B-cell development [25]

15

40594724-40628804

1R1, 3R, 15R

PLCB2

Activated by RAC1 to modulate Ca2+ signaling [26]

X

155003966-155250615

3R, 13R, 15R

VAMP7, IL9R

IL9R activates JAK-STAT signaling in response to IL9 [29]