Figure 5

Aberrantly expressed lncRNAs across human cancers. (A) Distribution of the number of cancer types in which LCALs are differentially expressed. All lung cohorts were considered as one cancer type, and x = 1 corresponds to differentially expressed in lung only. (B) Heatmap showing the distribution of differentially expressed LCALs across the three lung cohorts and seven additional TCGA cohorts. Black bars designate that an LCAL is differentially expressed in a given cancer. (C) Expression levels and fold changes for six LCALs that were experimentally validated. The size of each point is proportional to average FPKM expression across the tumors for up-regulated lncRNAs or across the normal tissues for down-regulated lncRNAs. Colors and symbols correspond to cancer type. Only cancer types in which the LCAL is differentially expressed are plotted. BRCA, breast invasive carcinoma; COAD, colon adenocarcinoma; HNSC, head and neck squamous cell carcinoma; KIRC, kidney renal clear cell carcinoma; STAD, stomach adenocarcinoma; THCA, thyroid carcinoma; UCEC, uterine corpus endometrial carcinoma.