Origin | Known or candidate cancer driver | Biallelic event | Allelic alteration 1 | Mutation or genomic aberration | Chr | Chr position or interval | Allelic alteration 2 |
---|---|---|---|---|---|---|---|
Unique to the primary | FGFR2* | Â | Amplification | 6-fold amplification | 10 | 117820033 - 119748751 | Â |
Common to the primary tumor and metastasis | CDH1 | Yes | Deletion | Partial deletion of exon 9 | 16 | 68847326 - 68847403 | Germline mutation in CDH1 |
TP53 | Yes | 5’ splice site mutation | Aberrant splicing | 17 | 7578370 | Hemizygous loss of 17p arm | |
Unique to the metastasis | TGFBR2 | Yes | Frameshift indel | Stop codon in exon 4 | 3 | 30691871 | Hemizygous deletion of wild-type TGFBR2 locus |
PCDH7 | Yes | Missense | S87R | 4 | 30723305 | Hemizygous deletion of wild-type 4 arm | |
FERMT1 loci | Yes | Loss of heterozygosity | FERMT1 located in 20p12.3 | 20 | Â | FERMT1 mutation | |
BMP7 loci | Yes | Loss of heterozygosity | BMP7 located in 20q13.3 | 20 | Â | BMP7 mutation |