Unique to the primary
|
FGFR2*
| |
Amplification
|
6-fold amplification
|
10
|
117820033 - 119748751
| |
Common to the primary tumor and metastasis
|
CDH1
|
Yes
|
Deletion
|
Partial deletion of exon 9
|
16
|
68847326 - 68847403
|
Germline mutation in CDH1
|
TP53
|
Yes
|
5’ splice site mutation
|
Aberrant splicing
|
17
|
7578370
|
Hemizygous loss of 17p arm
|
Unique to the metastasis
|
TGFBR2
|
Yes
|
Frameshift indel
|
Stop codon in exon 4
|
3
|
30691871
|
Hemizygous deletion of wild-type TGFBR2 locus
|
PCDH7
|
Yes
|
Missense
|
S87R
|
4
|
30723305
|
Hemizygous deletion of wild-type 4 arm
|
FERMT1 loci
|
Yes
|
Loss of heterozygosity
|
FERMT1 located in 20p12.3
|
20
| |
FERMT1 mutation
|
BMP7 loci
|
Yes
|
Loss of heterozygosity
|
BMP7 located in 20q13.3
|
20
| |
BMP7 mutation
|