Structural organization of SUMO-specific-proteases/isopeptidases. The domain organizations of Ulp/SENPs and Desi family members are shown. Green ovals represent the catalytic domain. The sequence determinants that are responsible for subcellular targeting are represented by orange ovals. The length of the proteins as total number of amino acids is presented on the right side. For the catalytic domains of SENP family members, sequence identity shared with SENP1 is also shown.