Figure 5

Application of MethylPurify to the lung adenocarcinoma samples. (a) Distribution of informative bins and the calculated minor components of five primary lung adenocarcinoma samples. (b) The numbers of DMBs inferred from normal-tumor comparison (blue, true DMB), predicted DMB by MethylPurify from only tumor tissue (red) and DMB inferred from TCGA (green) for each sample. (c-g) Violin plots show the distributions of CpG counts (c), read counts (d), tumor/normal methylation differences (e), tumor methylation levels (f), and numbers of lung adenocarcinoma samples with copy number alteration in TCGA (g) for false negative (FN), true positive (TP), false positive (FP), and true negative (TN) bins.