Figure 2

Parameter estimation and properties of informative bins. (a) Averaged standard deviations of three free parameters at different mixing ratios by bootstrap sampling of HCC (breast cancer) and HMEC (normal mammary epithelial) cell lines for all qualifying bins. (b) Predicted mixing ratios at different standard derivation cutoffs of the minor composition. (c, d) Some properties of informative bins compared with genome-wide background. (c) The number of CpG counts in informative bins vs. the rest bins with over 10 fold read coverage. (d) Distribution of predicted methylation levels of informative bins in each cell line.