Skip to main content
Figure 3 | Genome Biology

Figure 3

From: The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas

Figure 3

APOBEC1 induces a mutator phenotype in a human chronic myeloid leukemia cell line. Frequency of imatinib-resistant clones arising from 107 K562 cells expressing either mammalian APOBEC1s, AID, or a control plasmid seeded in the presence of 1 μM imatinib (control/APOBEC1, P < 0.05). Imatinib resistance was confirmed by growing the clones in imatinib-supplemented medium.

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us