A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Table 8 The correlation between the Jaccard index ( JI ) and paralog co-expression was robust in respect to the breadth of expression

The breadth of expression of paralogs	Pearson’s correlation betweenJIand paralog co-expression	t ^a	df ^b	n ^c	P-value
Both paralogs were tissue-specific	0.219	16.4535	5323	8023	< 2.2e-16
Both paralogs were intermediate	0.157	3.7538	551	663	0.000192
Both paralogs were housekeeping	0.217	8.0303	1297	1510	2.22E-15
One gene tissue-specific, the other housekeeping	0.324	15.4364	2026	2361	< 2.2e-16

NOTE: Transcripts were divided into tissue-specific (the breadth of expression ≤ 0.33), intermediate (0.33 < the breadth of expression ≤ 0.66), and house-keeping (the breadth of expression > 0.66).
^at-statistic.
^b degrees of freedom.
^c number of data-points.

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