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Figure 9 | Genome Biology

Figure 9

From: A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Figure 9

The correlation between BoE and TfbsNo. is recapitulated over evolution. This figure consists of four panels identified as a through d. Panel a shows a boxplot for BoE depending on age of gene duplication. Panel b shows a similar boxplot of TfbsNo. Young genes are more tissue-specific and have fewer TF binders. The correlation between TfbsNo. and BoE was strongest for young genes (Spearman rho = 0.531, 0.513, 0.46, 0.447, and 0.403 for increasingly older taxon groups, from primate through to eukaryotic genes). To explain the origins of additional tissue-specific genes in younger taxa, we divided duplication events into three subclasses: “housekeeping conserved”, “tissue − sp. conserved”, and “transformative”. Panels c and d show barplots for the three different mechanistic subtypes of gene duplication events (absolute numbers and relative proportions thereof, respectively).

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Genome Biology

ISSN: 1474-760X

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