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Figure 11 | Genome Biology

Figure 11

From: A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Figure 11

Conceptual diagram of the four classes of tissue-specific and broadly expressed transcripts rich or poor in transcription factor binding sites. The four classes were marked with A, B, C , and D. The cutoffs were as follows: ten transcription factor binding sites for Tfbs-rich, the breadth of expression of 0.33 for broadly expressed, and the TPM value of ten for a gene to be “on”. The breadth of expression was defined as the fraction of FANTOM5 human tissue samples in which a transcript was “on”. The biological interpretation of this figure was that typical housekeeping genes were Tfbs-rich, while typical tissue-specific genes were Tfbs-poor. The diagram uses Figure 5a as its background to illustrate the number of transcripts in each of the four classes. The four classes of transcripts will facilitate classification of transcription factors and their impact on individual genes as either activatory or inhibitory (Additional file 9: Table S2).

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