Figure 2

DNA methylation landscape in untreated cells. (a) Histogram of global percentage methylation. The genome is split into non-overlapping 2 kb windows, and the percentage methylation at CpGs calculated for each window. Y-axis indicates the number of windows with a given methylation level. (b) Proportion of individual CpGs that are unmethylated (<20% methylated), partially methylated (20% to 80% methylated) or methylated (>80% methylated). (c) Bisulphite sequencing percentage methylation (orange) and Ensembl genes (blue) over chromosome 16. (d) Ratios of observed to expected overlap (enrichment) of methylated, partially methylated and unmethylated CpGs (defined as in (b)) with specified genomic features.