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Figure 2 | Genome Biology

Figure 2

From: Seq and CLIP through the miRNA world

Figure 2

The multi-faceted miRNA biogenesis and miRNA interaction with targets. miRNAs are processed mainly by Drosha-DGCR8 in the canonical pathway, but also by the lariate-debranching enzyme in the nucleus, and by Dicer (from other non-coding RNAs such as tRNAs and snoRNAs) and Ago2 in the cytoplasm. Although miRISC generally regulates the stability and translation rate of target mRNAs, other long RNAs feed back on the miRNA regulation by sequestering miRNAs from their direct targets.

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