Figure 1

Overview of the cross-linking kinetic (CLK) method. Schematic showing a chromatin site (blue rectangle) interacting with a transcription factor (blue circle) in a population of six cells. Red 'X’ symbols denote cross-linking. The plot shows how the site occupancy in the population and the resulting ChIP signal are predicted to change after addition of formaldehyde for varying periods of time. (Adapted from Poorey et al. [2]). ChIP, chromatin immunoprecipitation; t, time; TF, transcription factor.