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Figure 5 | Genome Biology

Figure 5

From: Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

Figure 5

Relationships between hydroxymethylation changes under TET depletion conditions and histone mark occupancy. (A-C) Genes with changes in 5hmC after TET depletion were compared to subsets of genes with histone modifications (as marked) mapped previously in UD NCCIT cells [1]. Shown are the percentage of genes with 5hmC changes that overlap with the given histone modification, and the percentage of all promoters (or other features) with the given histone modification in the genome (total number of genes = 23,218; total genes with 5hmC changes per region are as listed in Figure 2B). 5hmC changes that have an overrepresentation or underrepresentation of the given histone mark are designated: *P < 0.0001 or ‡P < 0.001. (D) Ontology analyses of subsets of H3K27me3-marked genes with loss of 5hmC after siTET1 treatment and of (E) H3K4me3-marked genes with gain of 5hmC after siTET2 treatment.

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