Figure 2

Features of SoxN binding and SoxN direct targets. (A) Barplot representing genomic features hit by SoxN binding intervals. 'Mixed' indicates intervals hitting more than a single feature in different genes. (B) De novo motifs discovered in the SoxN core dataset. The top three motifs found and their associated P-values are reported. (C) Proportional Venn diagram showing the overlap between genes differentially expressed in SoxN mutants (green, left) and genes bound by SoxN (blue, right). (D) Dorsal, lateral and ventral views of SoxN expression in a stage 9-10 embryo (left, images from the Berkeley Drosophila Genome Project) and false-colour heatmaps representing the average expression pattern of SoxN direct targets at the same developmental stages. (E) Network showing known interactions between SoxN direct targets obtained by superimposing the list of SoxN direct targets with a network created from the DroID database. Genes are colour-coded according to their expression trend during the time-course (green, downregulated; red, upregulated; light blue, variable). SoxN and Dichaete are highlighted with yellow boxes.