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Table 3 Details of the 10 most heritable probes that do not contain any annotated SNPs

From: Contribution of genetic variation to transgenerational inheritance of DNA methylation

Probe ID

Chr

CpG position

h2

Genomic context

Type

HIL

#CpG

GWAS SNP

SNP position

Pvalue

cg15671450

6

29895116

0.934

Upstream (HCG4B)

II

HC

1

rs111482415

29923140

4.8 × 10-78

cg01903420

13

27295928

0.933

Intergenic

II

IC

2

rs1374010

27295317

3.0 × 10-105

cg03168497

17

48586147

0.932

Intronic (MYCBPAP)

II

HC

4

rs73351675

48585554

8.1 × 10-84

cg11064039

7

766100

0.932

Intronic (PRKAR1B)

I

HC

3

rs11763218

852281

8.8 × 10-58

cg24372256

21

43528868

0.931

Intronic (UMODL1)

II

IC

1

rs34212454

43529216

2.9 × 10-101

cg26764761

16

87682142

0.927

Intronic (JPH2)

I

IC

7

rs748554

87682775

1.4 × 10-107

cg16761754

14

105127242

0.927

Intergeneic

I

IC

3

rs4075355

105125512

1.8 × 10-77

cg21358336

17

6558440

0.927

Upstream (MIR4520B)/Downstream (MIR4520A)

II

ICshore

1

rs2040847

6558011

1.3 × 10-91

cg04118610

4

62707027

0.926

Intronic (LPHN3)

II

LC

2

rs10021525

62707476

2.1 × 10-105

cg08164151

12

131118432

0.925

Intergeneic

II

IC

3

rs10848167

131123623

2.9 × 10-101

  1. Genomic context of probes was annotated using ANNOVAR [24], with a probe being upstream or downstream defined as being within 2 KB of the transcription start site or transcription end site, respectively.
  2. GWAS SNP = Most significant SNP from GWAS; HIL = ‘HIL’ classification of CpG [22]; Type = Illumina HumanMethylation450 assay probe type.