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Table 3 Details of the 10 most heritable probes that do not contain any annotated SNPs

From: Contribution of genetic variation to transgenerational inheritance of DNA methylation

Probe ID Chr CpG position h2 Genomic context Type HIL #CpG GWAS SNP SNP position Pvalue
cg15671450 6 29895116 0.934 Upstream (HCG4B) II HC 1 rs111482415 29923140 4.8 × 10-78
cg01903420 13 27295928 0.933 Intergenic II IC 2 rs1374010 27295317 3.0 × 10-105
cg03168497 17 48586147 0.932 Intronic (MYCBPAP) II HC 4 rs73351675 48585554 8.1 × 10-84
cg11064039 7 766100 0.932 Intronic (PRKAR1B) I HC 3 rs11763218 852281 8.8 × 10-58
cg24372256 21 43528868 0.931 Intronic (UMODL1) II IC 1 rs34212454 43529216 2.9 × 10-101
cg26764761 16 87682142 0.927 Intronic (JPH2) I IC 7 rs748554 87682775 1.4 × 10-107
cg16761754 14 105127242 0.927 Intergeneic I IC 3 rs4075355 105125512 1.8 × 10-77
cg21358336 17 6558440 0.927 Upstream (MIR4520B)/Downstream (MIR4520A) II ICshore 1 rs2040847 6558011 1.3 × 10-91
cg04118610 4 62707027 0.926 Intronic (LPHN3) II LC 2 rs10021525 62707476 2.1 × 10-105
cg08164151 12 131118432 0.925 Intergeneic II IC 3 rs10848167 131123623 2.9 × 10-101
  1. Genomic context of probes was annotated using ANNOVAR [24], with a probe being upstream or downstream defined as being within 2 KB of the transcription start site or transcription end site, respectively.
  2. GWAS SNP = Most significant SNP from GWAS; HIL = ‘HIL’ classification of CpG [22]; Type = Illumina HumanMethylation450 assay probe type.