Interplay between genetic and non-genetic factors causing chromatin discordance. (A) Quantile-quantile plot of P values for local (<1 Mb) associations from the QTL mapping of chromatin discordance. The 5th and 95th percentiles of the beta distribution of the P values is shown (gray shading). Significant associations (FDR = 0.01) are denoted in blue. (B) The percentage of chromatin-state domains harboring the chromatin regions that are discordant depending on a local genotype. The number of such domains was divided by the total number of the domains containing the open chromatin regions used in our QTL mapping.