Figure 1

Effect of somatic mutations on chromatin regulation. (A) Within-pair differences in chromatin accessibility based on the presence and absence of mutations. (B) Correlation of chromatin discordance with the presence of mutations in open chromatin and in TFBSs as predicted based on Transfac position weight matrices, motif enrichment analysis by Homer, and ChIP-seq data in GM12878 lymphoblastoid cells. (C) Correlation of chromatin discordance with mutation types. (D,E) Within-pair differences in mutation rates (D) and chromatin accessibility (E) according to different regulatory states.