Early neoplasias in histological specimens. (A) Schematic of the morphology of early neoplasias, including columnar cell lesions (CCL) and atypical ductal hyperplasia (ADH), as well as later stage ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC). Usual ductal hyperplasia (UDH) and non-proliferative fibrocystic change (NPFCC) present benign hyperplasias of the breast. Normal breast is shown as terminal ductal lobular units (TDLU). (B) Workflow diagram for lesion purification and RNA isolation.