Splicing and transcription factors inferred from the 29 signature clusters induced by repeated cocaine and their interacting epigenomic marks. Splicing and transcription factors are indicated on the right panel by different colors. Green means the enrichment of a splicing factor on the left; red means the enrichment of a transcription factor on the right; blue means the enrichment of both. All 32 splicing factors and the top 32 transcription factors are shown here. Each column represents a signature cluster. The gene expression level for the regulators is labeled as 'Very High' (RPKM >20), 'High' (RPKM >5 and ≤20), 'Medium' (RPKM >1 and ≤5), and 'Low' (RPKM ≤1) based on our RNA-seq data. The chromatin marks that interact with the splicing factors are shown on the left panel by pink color.