Figure 4

Heatmap of cocaine-regulated chromatin modifications of the 29 signature clusters that associate with transcriptional regulation. In the left panel, each row represents a cluster and each column represents an epigenomic mark at a specific genomic region; each square represents the averaged chromatin modification change in log2 scale; purple and orange colors indicate increased or decreased binding and the darkness indicates the magnitude of change. The heatmap in the right panel illustrates the statistical significance of each cluster’s association with transcriptional change. N.S., not significant.